MolNFT v1 · #135722 · protein
Co-bound dihydroneopterin triphosphate pyrophosphohydrolase from E. COLI
5U7F · Dihydroneopterin triphosphate diphosphatase: “Co-bound dihydroneopterin triphosphate pyrophosphohydrolase from E. COLI”. X-ray diffraction, 2 ligands (CO, SO4), 1 pocket (best druggability 0.75). MolNFT v1 #135722 on GenesisL1: 3D…
- PDB
- 5U7F
- Type
- protein
- Length
- 144 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Dihydroneopterin triphosphate diphosphatase
- EC
- 3.6.1.67
- UniProt
- P0AFC1
- Ligands
- CO, SO4
- Pockets
- 1 · best druggability 0.75
Structure
x-ray diffraction · 1 distinct chain · 26% helix, 38% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Dihydroneopterin triphosphate diphosphatase (EC 3.6.1.67) | protein | 144 | 26% helix, 38% strand | P0AFC1 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 158 | 0.75 | 0.92 | 25 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 5U7F · Co-bound dihydroneopterin triphosphate pyrophosphohydrolase from E. coli · the same entry in another collection · chain A against A, TM-score 1.00
- P0AFC1 · AlphaFold monomer V2.0 prediction for dihydroneopterin triphosphate diphosphatase (P0AFC1) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0AFC1
- Elsewhere: RCSB PDB 5U7F · PDBe 5U7F · UniProt P0AFC1
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