MolNFT v1 · #135683 · protein
Structure of the axl kinase domain in complex with a macrocyclic inhibitor
5U6B: “Structure of the axl kinase domain in complex with a macrocyclic inhibitor”. X-ray diffraction, 1 ligand (7YS). MolNFT v1 #135683 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5U6B
- Type
- protein
- Length
- 1,122 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P30530
- Ligands
- 7YS
Structure
x-ray diffraction · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | — | protein | 270 | — | P30530 |
| B, D | — | protein | 291 | — | P30530 |
Ligands and binding sites
- 7YS · (10R)-7-amino-11-chloro-12-fluoro-1-(2-hydroxyethyl)-3, 10,16-trimethyl-16,17-dihydro-1H-8,4-(azeno) pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecin-15(10H)-one · ligand · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5U6B · Structure of the Axl kinase domain in complex with a macrocyclic inhibitor · the same entry in another collection · chain A against A, TM-score 1.00
- P30530 · AlphaFold monomer V2.0 prediction for tyrosine-protein kinase receptor ufo (P30530) · a predicted model of the same protein · chain B against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P30530
- Elsewhere: RCSB PDB 5U6B · PDBe 5U6B · UniProt P30530
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