MolNFT v1 · #135574 · protein + RNA
Crystal structure of AACC2C1-sgrna binary complex
5U34 · CRISPR-associated endonuclease C2C1: “Crystal structure of AACC2C1-sgrna binary complex”. X-ray diffraction, 19 pockets (best druggability 0.81). MolNFT v1 #135574 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5U34
- Type
- protein + RNA
- Length
- 1,038 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- CRISPR-associated endonuclease C2C1; Sgrna
- EC
- 3.1.-.-
- UniProt
- T0D7A2
- Pockets
- 19 · best druggability 0.81
Structure
x-ray diffraction · 2 distinct chains · 43% helix, 17% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | CRISPR-associated endonuclease C2C1 (EC 3.1.-.-) | protein | 960 | 43% helix, 17% strand | T0D7A2 |
| B | Sgrna | rna | 78 | — | — |
Pockets
19 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 251 | 0.81 | 0.93 | 40 | empty |
| 2 | 873 | 0.78 | 0.81 | 72 | empty |
| 3 | 658 | 0.70 | 0.78 | 50 | empty |
| 4 | 603 | 0.68 | 0.78 | 66 | empty |
| 5 | 457 | 0.67 | 0.80 | 27 | empty |
Interfaces
1 interface between chains.
- A–B · 4223 Ų buried · 98 hydrogen bonds · protein-nucleic
Modifications
Observed in the structure: 18 modified (engineered).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt T0D7A2
- Elsewhere: RCSB PDB 5U34 · PDBe 5U34 · UniProt T0D7A2
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