MolNFT v1 · #135490 · protein
C-terminal ankyrin repeats from human liver-type glutaminase (GAB/LGA)
5U0K · Glutaminase liver isoform, mitochondrial: “C-terminal ankyrin repeats from human liver-type glutaminase (GAB/LGA)”. X-ray diffraction, 4 pockets (best druggability 0.47). MolNFT v1 #135490 on GenesisL1: 3D structure, binding sites…
- PDB
- 5U0K
- Type
- protein
- Length
- 958 residues
- Chains
- 10
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glutaminase liver isoform, mitochondrial
- EC
- 3.5.1.2
- UniProt
- Q9UI32
- Pockets
- 4 · best druggability 0.47
Structure
x-ray diffraction · 7 distinct chains · 59% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, J | Glutaminase liver isoform, mitochondrial (EC 3.5.1.2) | protein | 98 | 60% helix, 0% strand | Q9UI32 |
| B | Glutaminase liver isoform, mitochondrial (EC 3.5.1.2) | protein | 95 | 59% helix, 0% strand | Q9UI32 |
| C, D | Glutaminase liver isoform, mitochondrial (EC 3.5.1.2) | protein | 94 | 59% helix, 0% strand | Q9UI32 |
| E | Glutaminase liver isoform, mitochondrial (EC 3.5.1.2) | protein | 96 | 60% helix, 0% strand | Q9UI32 |
| F, H | Glutaminase liver isoform, mitochondrial (EC 3.5.1.2) | protein | 95 | 56% helix, 0% strand | Q9UI32 |
| G | Glutaminase liver isoform, mitochondrial (EC 3.5.1.2) | protein | 96 | 56% helix, 0% strand | Q9UI32 |
| I | Glutaminase liver isoform, mitochondrial (EC 3.5.1.2) | protein | 97 | 61% helix, 0% strand | Q9UI32 |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 226 | 0.47 | 0.74 | 33 | empty |
| 2 | 230 | 0.47 | 0.73 | 35 | empty |
| 3 | 111 | 0.40 | 0.75 | 18 | empty |
| 4 | 55 | 0.27 | 0.73 | 13 | empty |
Interfaces
14 interfaces between chains.
- G–I · 916 Ų buried · 14 hydrogen bonds · protein-protein
- B–C · 889 Ų buried · 14 hydrogen bonds · protein-protein
- H–J · 850 Ų buried · 12 hydrogen bonds · protein-protein
- D–E · 832 Ų buried · 13 hydrogen bonds · protein-protein
- A–F · 821 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 5U0K · C-terminal ankyrin repeats from human liver-type glutaminase (GAB/LGA) · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UI32 · AlphaFold monomer V2.0 prediction for glutaminase liver isoform, mitochondrial (Q9UI32) · a predicted model of the same protein · chain C against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UI32
- Elsewhere: RCSB PDB 5U0K · PDBe 5U0K · UniProt Q9UI32
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