MolNFT v1 · #135440 · protein

Crystal structure of curk dehydratase H996F inactive mutant

5TZ5: “Crystal structure of curk dehydratase H996F inactive mutant”. X-ray diffraction, 6 pockets (best druggability 0.74). MolNFT v1 #135440 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5TZ5
Type: protein
Length: 560 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Curk
UniProt: F4Y425
Pockets: 6 · best druggability 0.74

Structure

x-ray diffraction · 2 distinct chains · 22% helix, 41% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Curk	protein	281	20% helix, 42% strand	F4Y425
B	Curk	protein	279	24% helix, 41% strand	F4Y425

Pockets

6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	183	0.74	0.91	29	empty
2	136	0.74	0.93	39	empty
3	140	0.53	0.80	26	empty
4	67	0.48	0.84	18	empty
5	99	0.45	0.80	17	empty

Interfaces

1 interface between chains.

A–B · 752 Å² buried · 19 hydrogen bonds · protein-protein

Compared structures

5TZ5 · Crystal Structure of CurK Dehydratase H996F Inactive Mutant · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt F4Y425
Elsewhere: RCSB PDB 5TZ5 · PDBe 5TZ5 · UniProt F4Y425

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