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Crystal structure of curk dehydratase H996F inactive mutant
Analyse Crystal structure of curk dehydratase H996F inactive mutant in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 5TZ5
- Type
- protein
- Length
- 560 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Curk
- UniProt
- F4Y425
- Pockets
- 6 · best druggability 0.74
Structure
x-ray diffraction · 2 distinct chains · 22% helix, 41% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Curk | protein | 281 | 20% helix, 42% strand | F4Y425 |
| B | Curk | protein | 279 | 24% helix, 41% strand | F4Y425 |
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 183 | 0.74 | 0.91 | 29 | empty |
| 2 | 136 | 0.74 | 0.93 | 39 | empty |
| 3 | 140 | 0.53 | 0.80 | 26 | empty |
| 4 | 67 | 0.48 | 0.84 | 18 | empty |
| 5 | 99 | 0.45 | 0.80 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 752 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 5TZ5 · Crystal Structure of CurK Dehydratase H996F Inactive Mutant · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt F4Y425
- Elsewhere: RCSB PDB 5TZ5 · PDBe 5TZ5 · UniProt F4Y425
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