MolNFT v1 · #13540 · protein
Crystal structure of MAP kinase P38 complexed to the docking site on its activator MKK3B
1LEZ · Mitogen-activated protein kinase 14: “Crystal structure of MAP kinase P38 complexed to the docking site on its activator MKK3B”. X-ray diffraction, 4 pockets (best druggability 0.66). MolNFT v1 #13540 on GenesisL1: 3D structure…
- PDB
- 1LEZ
- Type
- protein
- Length
- 351 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitogen-activated protein kinase 14; MAP kinase kinase 3B
- EC
- 2.7.1.-
- UniProt
- P47811
- Pockets
- 4 · best druggability 0.66
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mitogen-activated protein kinase 14 (EC 2.7.1.-) | protein | 343 | 41% helix, 15% strand | P47811 |
| B | MAP kinase kinase 3B | protein | 8 | 0% helix, 0% strand | — |
Pockets
4 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 302 | 0.66 | 0.81 | 42 | empty |
| 2 | 176 | 0.51 | 0.77 | 18 | empty |
| 3 | 243 | 0.50 | 0.75 | 39 | empty |
| 4 | 56 | 0.28 | 0.74 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 499 Ų buried · 6 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 1LEZ · Crystal structure of MAP kinase P38 complexed to the docking site on its activator MKK3B · the same entry in another collection · chain A against A, TM-score 1.00
- P47811 · AlphaFold monomer V2.0 prediction for mitogen-activated protein kinase 14 (P47811) · a predicted model of the same protein · chain A against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P47811
- Elsewhere: RCSB PDB 1LEZ · PDBe 1LEZ · UniProt P47811
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.