MolNFT v1 · #135376 · protein

ATXE2 isopeptidase - apo

5TXC: “ATXE2 isopeptidase - apo”. X-ray diffraction, 12 pockets (best druggability 0.75). MolNFT v1 #135376 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5TXC
Type: protein
Length: 1,306 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: ATXE2
EC: 3.4.21.-
UniProt: E8RUP5
Pockets: 12 · best druggability 0.75

Structure

x-ray diffraction · 1 distinct chain · 26% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	ATXE2 (EC 3.4.21.-)	protein	653	26% helix, 32% strand	E8RUP5

Pockets

12 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1118	0.75	0.78	98	empty
2	554	0.73	0.81	37	empty
3	621	0.70	0.78	55	empty
4	820	0.70	0.76	87	empty
5	332	0.64	0.80	51	empty

Interfaces

1 interface between chains.

A–B · 1606 Å² buried · 15 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

5TXC · AtxE2 Isopeptidase - APO · the same entry in another collection · chain A against A, TM-score 1.00
E8RUP5 · AlphaFold monomer V2.0 prediction for lasso peptide isopeptidase ATXE2 (E8RUP5) · a predicted model of the same protein · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt E8RUP5
Elsewhere: RCSB PDB 5TXC · PDBe 5TXC · UniProt E8RUP5

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