MolNFT v1 · #13537 · protein
Crystal structure of MAP kinase P38 complexed to the docking site on its nuclear substrate MEF2A
1LEW · Mitogen-activated protein kinase 14: “Crystal structure of MAP kinase P38 complexed to the docking site on its nuclear substrate MEF2A”. X-ray diffraction, 4 pockets (best druggability 0.65). MolNFT v1 #13537 on GenesisL1: 3D…
- PDB
- 1LEW
- Type
- protein
- Length
- 351 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitogen-activated protein kinase 14; Myocyte-specific enhancer factor 2A
- EC
- 2.7.11.24
- UniProt
- P47811, Q02078
- Pockets
- 4 · best druggability 0.65
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mitogen-activated protein kinase 14 (EC 2.7.11.24) | protein | 341 | 41% helix, 16% strand | P47811 |
| B | Myocyte-specific enhancer factor 2A | protein | 10 | 0% helix, 0% strand | Q02078 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 383 | 0.65 | 0.79 | 44 | empty |
| 2 | 257 | 0.53 | 0.76 | 41 | empty |
| 3 | 64 | 0.49 | 0.85 | 15 | empty |
| 4 | 112 | 0.41 | 0.76 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 569 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 1LEW · Crystal structure of MAP kinase P38 complexed to the docking site on its nuclear… · the same entry in another collection · chain A against A, TM-score 1.00
- P47811 · AlphaFold monomer V2.0 prediction for mitogen-activated protein kinase 14 (P47811) · a predicted model of the same protein · chain A against A, TM-score 0.97
- Q02078 · AlphaFold monomer V2.0 prediction for myocyte-specific enhancer factor 2A (Q02078) · a predicted model of the same protein · chain B against A, TM-score 0.46
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P47811
- Every structure of UniProt Q02078
- Elsewhere: RCSB PDB 1LEW · PDBe 1LEW · UniProt P47811 · UniProt Q02078
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.