MolNFT v1 · #135362 · protein
Structure of maternal embryonic leucine zipper kinase
5TWU: “Structure of maternal embryonic leucine zipper kinase”. X-ray diffraction, 6 pockets (best druggability 0.75). MolNFT v1 #135362 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5TWU
- Type
- protein
- Length
- 633 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Maternal embryonic leucine zipper kinase
- EC
- 2.7.11.1, 2.7.10.2
- UniProt
- Q14680
- Pockets
- 6 · best druggability 0.75
Structure
x-ray diffraction · 2 distinct chains · 45% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Maternal embryonic leucine zipper kinase (EC 2.7.11.1, 2.7.10.2) | protein | 318 | 44% helix, 14% strand | Q14680 |
| B | Maternal embryonic leucine zipper kinase (EC 2.7.11.1, 2.7.10.2) | protein | 315 | 45% helix, 15% strand | Q14680 |
Pockets
6 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 514 | 0.75 | 0.83 | 52 | empty |
| 2 | 503 | 0.75 | 0.83 | 56 | empty |
| 3 | 337 | 0.65 | 0.80 | 39 | empty |
| 4 | 271 | 0.63 | 0.81 | 30 | empty |
| 5 | 73 | 0.36 | 0.76 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 1404 Ų buried · 24 hydrogen bonds · protein-protein
Compared structures
- 5TWU · Structure of Maternal Embryonic Leucine Zipper Kinase · the same entry in another collection · chain A against A, TM-score 1.00
- Q14680 · AlphaFold monomer V2.0 prediction for maternal embryonic leucine zipper kinase (Q14680) · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14680
- Elsewhere: RCSB PDB 5TWU · PDBe 5TWU · UniProt Q14680
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