MolNFT v1 · #135325 · protein
Structure of maternal embryonic leucine zipper kinase
5TVT: “Structure of maternal embryonic leucine zipper kinase”. X-ray diffraction, 1 ligand (7LV), 3 pockets (best druggability 0.64). MolNFT v1 #135325 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5TVT
- Type
- protein
- Length
- 321 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Maternal embryonic leucine zipper kinase
- EC
- 2.7.11.1, 2.7.10.2
- UniProt
- Q14680
- Ligands
- 7LV
- Pockets
- 3 · best druggability 0.64
Structure
x-ray diffraction · 1 distinct chain · 44% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Maternal embryonic leucine zipper kinase (EC 2.7.11.1, 2.7.10.2) | protein | 321 | 44% helix, 15% strand | Q14680 |
Ligands and binding sites
- 7LV · 9-(3,5-dichloro-4-hydroxyphenyl)-1-{trans-4-[(dimethylamino)methyl]cyclohexyl}-3-methyl-3,4-dihydropyrimido[5,4-c][1,5]naphthyridin-2(1H)-one · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 309 | 0.64 | 0.80 | 37 | 7LV |
| 2 | 346 | 0.59 | 0.76 | 41 | empty |
| 3 | 55 | 0.31 | 0.76 | 11 | empty |
Compared structures
- 5TVT · Structure of Maternal Embryonic Leucine Zipper Kinase · the same entry in another collection · chain A against A, TM-score 1.00
- Q14680 · AlphaFold monomer V2.0 prediction for maternal embryonic leucine zipper kinase (Q14680) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14680
- Elsewhere: RCSB PDB 5TVT · PDBe 5TVT · UniProt Q14680
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