MolNFT v1 · #135267 · protein
Pagf prenyltransferase with tyr-tyr-tyr and dmspp
5TU5: “Pagf prenyltransferase with tyr-tyr-tyr and dmspp”. X-ray diffraction, 2 ligands (DST, MG), 2 pockets (best druggability 0.66). MolNFT v1 #135267 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5TU5
- Type
- protein
- Length
- 300 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Pagf prenyltransferase; Tyr-tyr-tyr
- UniProt
- F5B6Z0
- Ligands
- DST, MG
- Pockets
- 2 · best druggability 0.66
Structure
x-ray diffraction · 2 distinct chains · 42% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Pagf prenyltransferase | protein | 297 | 42% helix, 29% strand | F5B6Z0 |
| B | Tyr-tyr-tyr | protein | 3 | 0% helix, 0% strand | — |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 249 | 0.66 | 0.83 | 37 | DST, MG |
| 2 | 139 | 0.50 | 0.79 | 26 | empty |
Interfaces
1 interface between chains.
- A–B · 404 Ų buried · 3 hydrogen bonds · protein-protein
Compared structures
- 5TU5 · PagF prenyltransferase with Tyr-Tyr-Tyr and DMSPP · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt F5B6Z0
- Elsewhere: RCSB PDB 5TU5 · PDBe 5TU5 · UniProt F5B6Z0
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