MolNFT v1 · #135255 · protein

Cryo-EM structure of msba-nanodisc with ADP-vanadate

5TTP · Lipid a export ATP-BINDING/PERMEASE protein msba: “Cryo-EM structure of msba-nanodisc with ADP-vanadate”. Electron microscopy, 14 pockets (best druggability 0.81). MolNFT v1 #135255 on GenesisL1: 3D structure, binding sites and…

PDB: 5TTP
Type: protein
Length: 1,138 residues
Chains: 2
Method: electron microscopy
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Lipid a export ATP-BINDING/PERMEASE protein msba
EC: 3.6.3.-
UniProt: P60753
Pockets: 14 · best druggability 0.81

Structure

electron microscopy · 1 distinct chain · 61% helix, 4% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Lipid a export ATP-BINDING/PERMEASE protein msba (EC 3.6.3.-)	protein	569	61% helix, 4% strand	P60753

Pockets

14 pockets found on a 1 Å grid, 11 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	961	0.81	0.83	141	empty
2	675	0.77	0.83	113	empty
3	454	0.74	0.83	81	empty
4	388	0.72	0.83	59	empty
5	357	0.69	0.82	69	empty

Interfaces

1 interface between chains.

A–B · 1515 Å² buried · 1 hydrogen bond · protein-protein

Compared structures

5TTP · Cryo-EM structure of MsbA-nanodisc with ADP-vanadate · the same entry in another collection · chain A against A, TM-score 1.00
P60753 · AlphaFold monomer V2.0 prediction for ATP-dependent lipid a-core flippase (P60753) · a predicted model of the same protein · chain A against A, TM-score 0.69

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P60753
Elsewhere: RCSB PDB 5TTP · PDBe 5TTP · UniProt P60753

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.