MolNFT v1 · #135229 · protein
Active conformation for engineered human cystathionine gamma lyase (E59N, R119L, E339V) to depleting methionine
5TSU: “Active conformation for engineered human cystathionine gamma lyase (E59N, R119L, E339V) to depleting…”. X-ray diffraction, 2 ligands (LPI, SO4). MolNFT v1 #135229 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5TSU
- Type
- protein
- Length
- 3,081 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- P32929
- Ligands
- LPI, SO4
Structure
x-ray diffraction · 8 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 385 | — | P32929 |
| B | — | protein | 385 | — | P32929 |
| C | — | protein | 386 | — | P32929 |
| D | — | protein | 384 | — | P32929 |
| E | — | protein | 385 | — | P32929 |
| F | — | protein | 382 | — | P32929 |
| G | — | protein | 387 | — | P32929 |
| H | — | protein | 387 | — | P32929 |
Ligands and binding sites
- LPI · N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)-L-methionine · ligand · 2 copies · chains C, D, E, F
- SO4 · Sulfate ion · ion · 3 copies · chains A, B, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5TSU · Active conformation for Engineered human cystathionine gamma lyase (E59N, R119L, E339V)… · the same entry in another collection · chain B against B, TM-score 1.00
- P32929 · AlphaFold monomer V2.0 prediction for cystathionine gamma-lyase (P32929) · a predicted model of the same protein · chain C against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P32929
- Elsewhere: RCSB PDB 5TSU · PDBe 5TSU · UniProt P32929
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