MolNFT v1 · #135183 · protein
MDM2 in complex with SAR405838
5TRF: “MDM2 in complex with SAR405838”. X-ray diffraction, 2 ligands (7HC, SO4). MolNFT v1 #135183 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5TRF
- Type
- protein
- Length
- 497 residues
- Chains
- 5
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q00987
- Ligands
- 7HC, SO4
Structure
x-ray diffraction · 5 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 98 | — | Q00987 |
| B | — | protein | 100 | — | Q00987 |
| C | — | protein | 100 | — | Q00987 |
| D | — | protein | 98 | — | Q00987 |
| E | — | protein | 101 | — | Q00987 |
Ligands and binding sites
- 7HC · (2'S,3R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-N-(trans-4-hydroxycyclohexyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide · ligand · 5 copies · chains A, B, C, D, E
- SO4 · Sulfate ion · ion · 3 copies · chains A, C, E
- GOL · Glycerol · additive · 7 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5TRF · MDM2 in complex with SAR405838 · the same entry in another collection · chain D against D, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q00987
- Elsewhere: RCSB PDB 5TRF · PDBe 5TRF · UniProt Q00987
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