Ligand · 7HC

7HC · (2'S,3R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-N-(trans-4-hydroxycyclohexyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide

7HC, (2'S,3R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-N-(trans-4-hydroxycyclohexyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide (C29 H34 Cl2 F N3 O3, 562.5 g/mol), in the MolNFT structures…

Component: 7HC
Formula: C29 H34 Cl2 F N3 O3
Class: ligand
Structures: 2
PDB entries: 1

Binding sites

7HC in 2 structures; the first of them:

5TRF · MDM2 in complex with SAR405838 · 7HC A201 · binds VAL14, THR15, THR16, LEU54, LEU57, GLY58, ILE61, MET62 and 10 more
5TRF · MDM2 in complex with SAR405838 · 7HC A201 · binds VAL14, THR16, LEU54, LEU57, GLY58, ILE61, MET62, TYR67 and 8 more

Residues it binds most

ILE 10, VAL 10, LEU 10, PHE 10, TYR 10, HIS 10, THR 10, GLY 10, MET 9, LYS 5 (residue and the binding sites it lines).

Found with

SO4 · Sulfate ion
GOL · Glycerol

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