MolNFT v1 · #135169 · protein
Lipoxygenase-1 (soybean) L754A mutant at 293K
5TR0 · Seed linoleate 13S-lipoxygenase-1: “Lipoxygenase-1 (soybean) L754A mutant at 293K”. X-ray diffraction, 1 ligand (FE2), 20 pockets (best druggability 0.83). MolNFT v1 #135169 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 5TR0
- Type
- protein
- Length
- 1,637 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Seed linoleate 13S-lipoxygenase-1
- EC
- 1.13.11.12
- UniProt
- P08170
- Ligands
- FE2
- Pockets
- 20 · best druggability 0.83
Structure
x-ray diffraction · 2 distinct chains · 42% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Seed linoleate 13S-lipoxygenase-1 (EC 1.13.11.12) | protein | 820 | 42% helix, 15% strand | P08170 |
| B | Seed linoleate 13S-lipoxygenase-1 (EC 1.13.11.12) | protein | 817 | 42% helix, 15% strand | P08170 |
Ligands and binding sites
- FE2 · Fe (II) ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 10 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 789 | 0.83 | 0.86 | 71 | empty |
| 2 | 815 | 0.83 | 0.85 | 70 | empty |
| 3 | 1159 | 0.81 | 0.82 | 112 | empty |
| 4 | 60 | 0.73 | 0.98 | 21 | empty |
| 5 | 52 | 0.71 | 0.98 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 585 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08170
- Elsewhere: RCSB PDB 5TR0 · PDBe 5TR0 · UniProt P08170
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