MolNFT v1 · #135158 · protein
Lipoxygenase-1 (soybean) L546A/L754A mutant at 300K
5TQO · Seed linoleate 13S-lipoxygenase-1: “Lipoxygenase-1 (soybean) L546A/L754A mutant at 300K”. X-ray diffraction, 1 ligand (FE), 20 pockets (best druggability 0.83). MolNFT v1 #135158 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 5TQO
- Type
- protein
- Length
- 1,639 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Seed linoleate 13S-lipoxygenase-1
- EC
- 1.13.11.12
- UniProt
- P08170
- Ligands
- FE
- Pockets
- 20 · best druggability 0.83
Structure
x-ray diffraction · 2 distinct chains · 42% helix, 15% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Seed linoleate 13S-lipoxygenase-1 (EC 1.13.11.12) | protein | 819 | 43% helix, 15% strand | P08170 |
| B | Seed linoleate 13S-lipoxygenase-1 (EC 1.13.11.12) | protein | 820 | 41% helix, 15% strand | P08170 |
Ligands and binding sites
- FE · Fe (III) ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
20 pockets found on a 1 Å grid, 12 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 670 | 0.83 | 0.87 | 55 | empty |
| 2 | 790 | 0.83 | 0.86 | 69 | empty |
| 3 | 1060 | 0.81 | 0.82 | 115 | empty |
| 4 | 136 | 0.80 | 0.97 | 26 | empty |
| 5 | 109 | 0.78 | 0.97 | 24 | empty |
Interfaces
1 interface between chains.
- A–B · 570 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08170
- Elsewhere: RCSB PDB 5TQO · PDBe 5TQO · UniProt P08170
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.