MolNFT v1 · #135152 · protein
IDH1 R132H mutant in complex with IDH889
5TQH: “IDH1 R132H mutant in complex with IDH889”. X-ray diffraction, 2 ligands (7J2, NDP). MolNFT v1 #135152 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5TQH
- Type
- protein
- Length
- 1,618 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- O75874
- Ligands
- 7J2, NDP
Structure
x-ray diffraction · 4 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 401 | — | O75874 |
| B | — | protein | 407 | — | O75874 |
| C | — | protein | 408 | — | O75874 |
| D | — | protein | 402 | — | O75874 |
Ligands and binding sites
- 7J2 · (4S)-3-[2-({(1S)-1-[5-(4-fluoro-3-methylphenyl) pyrimidin-2-yl]ethyl}amino)pyrimidin-4-yl]-4-(propan-2-yl)-1,3-oxazolidin-2-one · ligand · 4 copies · chains A, C, B, D
- NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate · ligand · 4 copies · chains A, B, D, C
- FLC · Citrate anion · additive · 4 copies · chains A, B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- O75874 · AlphaFold monomer V2.0 prediction for isocitrate dehydrogenase [NADP] cytoplasmic (O75874) · a predicted model of the same protein · chain B against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O75874
- Elsewhere: RCSB PDB 5TQH · PDBe 5TQH · UniProt O75874
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