MolNFT v1 · #135138 · protein

Phospholipase C gamma-1 C-terminal SH2 domain bound to a phosphopeptide derived from the insulin receptor

5TQ1 · 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase…: “Phospholipase C gamma-1 C-terminal SH2 domain bound to a phosphopeptide derived from the insulin receptor”. X-ray diffraction. MolNFT v1 #135138 on GenesisL1: 3D…

PDB: 5TQ1
Type: protein
Length: 109 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; Insulin receptor
EC: 3.1.4.11
UniProt: P08487, Q9R1H1

Structure

x-ray diffraction · 2 distinct chains · 22% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11)	protein	101	24% helix, 36% strand	P08487
B	Insulin receptor	protein	8	0% helix, 0% strand	Q9R1H1

Interfaces

1 interface between chains.

A–B · 447 Å² buried · 11 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 modified (phosphorylation).

Compared structures

5TQ1 · Phospholipase C gamma-1 C-terminal SH2 domain bound to a phosphopeptide derived from the… · the same entry in another collection · chain A against A, TM-score 1.00
P08487 · AlphaFold monomer V2.0 prediction for 1-phosphatidylinositol 4,5-bisphosphate… · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08487
Every structure of UniProt Q9R1H1
Elsewhere: RCSB PDB 5TQ1 · PDBe 5TQ1 · UniProt P08487 · UniProt Q9R1H1

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