MolNFT v1 · #135130 · protein
The crystal structure of amyloid precursor-like protein 2 (APLP2) E2 domain
5TPT · Amyloid-like protein 2: “The crystal structure of amyloid precursor-like protein 2 (APLP2) E2 domain”. X-ray diffraction, 4 pockets (best druggability 0.73). MolNFT v1 #135130 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 5TPT
- Type
- protein
- Length
- 378 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Amyloid-like protein 2
- UniProt
- Q06481
- Pockets
- 4 · best druggability 0.73
Structure
x-ray diffraction · 2 distinct chains · 87% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Amyloid-like protein 2 | protein | 197 | 87% helix, 0% strand | Q06481 |
| B | Amyloid-like protein 2 | protein | 181 | 88% helix, 0% strand | Q06481 |
Pockets
4 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 544 | 0.73 | 0.81 | 55 | empty |
| 2 | 527 | 0.69 | 0.79 | 55 | empty |
| 3 | 403 | 0.64 | 0.78 | 41 | empty |
| 4 | 264 | 0.55 | 0.76 | 33 | empty |
Interfaces
1 interface between chains.
- A–B · 1276 Ų buried · 24 hydrogen bonds · protein-protein
Compared structures
- 5TPT · The Crystal Structure of Amyloid Precursor-Like Protein 2 (APLP2) E2 Domain · the same entry in another collection · chain A against A, TM-score 1.00
- Q06481 · AlphaFold monomer V2.0 prediction for amyloid-like protein 2 (Q06481) · a predicted model of the same protein · chain B against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q06481
- Elsewhere: RCSB PDB 5TPT · PDBe 5TPT · UniProt Q06481
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