MolNFT v1 · #135113 · protein
Solution structure of the CAM34 with the inos cam binding domain peptide
5TP6 · Calmodulin: “Solution structure of the CAM34 with the inos cam binding domain peptide”. Solution nmr, 4 pockets (best druggability 0.46). MolNFT v1 #135113 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5TP6
- Type
- protein
- Length
- 177 residues
- Chains
- 2
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Calmodulin; Nitric oxide synthase, inducible
- EC
- 1.14.13.39
- UniProt
- P62158, P35228
- Pockets
- 4 · best druggability 0.46
Structure
solution nmr · 2 distinct chains · 47% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Calmodulin | protein | 148 | 52% helix, 3% strand | P62158 |
| B | Nitric oxide synthase, inducible (EC 1.14.13.39) | protein | 29 | 24% helix, 0% strand | P35228 |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 128 | 0.46 | 0.78 | 20 | empty |
| 2 | 85 | 0.44 | 0.80 | 20 | empty |
| 3 | 106 | 0.37 | 0.74 | 19 | empty |
| 4 | 62 | 0.30 | 0.74 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 1565 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 5TP6 · Solution structure of the CaM34 with the iNOS CaM binding domain peptide · the same entry in another collection · chain A against A, TM-score 1.00
- P35228 · AlphaFold monomer V2.0 prediction for nitric oxide synthase, inducible (P35228) · a predicted model of the same protein · chain B against A, TM-score 0.37
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P62158
- Every structure of UniProt P35228
- Elsewhere: RCSB PDB 5TP6 · PDBe 5TP6 · UniProt P62158 · UniProt P35228
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.