MolNFT v1 · #135072 · protein

Phospholipase C gamma-1 C-terminal SH2 domain

5TNW · 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase…: “Phospholipase C gamma-1 C-terminal SH2 domain”. X-ray diffraction, 1 pocket (best druggability 0.53). MolNFT v1 #135072 on GenesisL1: 3D structure, binding sites and…

PDB: 5TNW
Type: protein
Length: 200 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1
EC: 3.1.4.11
UniProt: P08487
Pockets: 1 · best druggability 0.53

Structure

x-ray diffraction · 1 distinct chain · 21% helix, 37% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (EC 3.1.4.11)	protein	100	21% helix, 37% strand	P08487

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	272	0.53	0.75	38	empty

Interfaces

1 interface between chains.

A–B · 550 Å² buried · 15 hydrogen bonds · protein-protein

Compared structures

5TNW · Phospholipase C gamma-1 C-terminal SH2 domain · the same entry in another collection · chain A against A, TM-score 1.00
P08487 · AlphaFold monomer V2.0 prediction for 1-phosphatidylinositol 4,5-bisphosphate… · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08487
Elsewhere: RCSB PDB 5TNW · PDBe 5TNW · UniProt P08487

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