MolNFT v1 · #134905 · protein
Crystal structure of syk kinase domain with inhibitor
5TIU · Tyrosine-protein kinase syk: “Crystal structure of syk kinase domain with inhibitor”. X-ray diffraction, 1 ligand (7CU), 2 pockets (best druggability 0.49). MolNFT v1 #134905 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 5TIU
- Type
- protein
- Length
- 266 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine-protein kinase syk
- EC
- 2.7.10.2
- UniProt
- P43405
- Ligands
- 7CU
- Pockets
- 2 · best druggability 0.49
Structure
x-ray diffraction · 1 distinct chain · 42% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein kinase syk (EC 2.7.10.2) | protein | 266 | 42% helix, 20% strand | P43405 |
Ligands and binding sites
- 7CU · 5-{[(2S)-2-aminopropyl]amino}-3-(1H-indol-2-yl) pyrazine-2-carboxamide · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 121 | 0.49 | 0.79 | 23 | 7CU |
| 2 | 72 | 0.28 | 0.72 | 15 | empty |
Compared structures
- 5TIU · Crystal structure of SYK kinase domain with inhibitor · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P43405
- Elsewhere: RCSB PDB 5TIU · PDBe 5TIU · UniProt P43405
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