MolNFT v1 · #134797 · protein
Crystal structure of the zika virus NS2B-NS3 protease with a deletion V76-L86 in NS2B
5TFO · NS2B-NS3 protease CHIMERA,NS2B-NS3 PROTEASE,NS2B-NS3…: “Crystal structure of the zika virus NS2B-NS3 protease with a deletion V76-L86 in NS2B”. X-ray diffraction, 2 pockets (best druggability 0.72). MolNFT v1 #134797 on GenesisL1…
- PDB
- 5TFO
- Type
- protein
- Length
- 320 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- NS2B-NS3 protease CHIMERA,NS2B-NS3 PROTEASE,NS2B-NS3 protease chimera
- UniProt
- Q32ZE1
- Pockets
- 2 · best druggability 0.72
Structure
x-ray diffraction · 2 distinct chains · 3% helix, 46% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | NS2B-NS3 protease CHIMERA,NS2B-NS3 PROTEASE,NS2B-NS3 protease chimera | protein | 162 | 2% helix, 46% strand | Q32ZE1 |
| B | NS2B-NS3 protease CHIMERA,NS2B-NS3 PROTEASE,NS2B-NS3 protease chimera | protein | 158 | 3% helix, 46% strand | Q32ZE1 |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 595 | 0.72 | 0.80 | 82 | empty |
| 2 | 266 | 0.59 | 0.78 | 43 | empty |
Interfaces
1 interface between chains.
- A–B · 808 Ų buried · 6 hydrogen bonds · protein-protein
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q32ZE1
- Elsewhere: RCSB PDB 5TFO · PDBe 5TFO · UniProt Q32ZE1
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