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Crystal structure of the zika virus NS2B-NS3 protease with a deletion V76-L86 in NS2B

Analyse Crystal structure of the zika virus NS2B-NS3 protease with a deletion V76-L86… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.

PDB: 5TFO
Type: protein
Length: 320 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: NS2B-NS3 protease CHIMERA,NS2B-NS3 PROTEASE,NS2B-NS3 protease chimera
UniProt: Q32ZE1
Pockets: 2 · best druggability 0.72

Structure

x-ray diffraction · 2 distinct chains · 3% helix, 46% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	NS2B-NS3 protease CHIMERA,NS2B-NS3 PROTEASE,NS2B-NS3 protease chimera	protein	162	2% helix, 46% strand	Q32ZE1
B	NS2B-NS3 protease CHIMERA,NS2B-NS3 PROTEASE,NS2B-NS3 protease chimera	protein	158	3% helix, 46% strand	Q32ZE1

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	595	0.72	0.80	82	empty
2	266	0.59	0.78	43	empty

Interfaces

1 interface between chains.

A–B · 808 Å² buried · 6 hydrogen bonds · protein-protein

Compared structures

5TFO · CRYSTAL STRUCTURE OF THE ZIKA VIRUS NS2B-NS3 PROTEASE with a deletion V76-L86 in NS2b · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q32ZE1
Elsewhere: RCSB PDB 5TFO · PDBe 5TFO · UniProt Q32ZE1

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