MolNFT v1 · #134794 · protein
Crystal structure of mouse cadherin-23 EC7+8
5TFL: “Crystal structure of mouse cadherin-23 EC7+8”. X-ray diffraction, 2 ligands (CA, NA), 3 pockets (best druggability 0.42). MolNFT v1 #134794 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5TFL
- Type
- protein
- Length
- 400 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Cadherin-23
- UniProt
- Q99PF4
- Ligands
- CA, NA
- Pockets
- 3 · best druggability 0.42
Structure
x-ray diffraction · 2 distinct chains · 6% helix, 45% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Cadherin-23 | protein | 202 | 6% helix, 44% strand | Q99PF4 |
| B | Cadherin-23 | protein | 198 | 6% helix, 45% strand | Q99PF4 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 147 | 0.42 | 0.74 | 23 | empty |
| 2 | 91 | 0.34 | 0.74 | 21 | empty |
| 3 | 52 | 0.28 | 0.75 | 15 | empty |
Interfaces
1 interface between chains.
- A–B · 696 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 5TFL · Crystal Structure of Mouse Cadherin-23 EC7+8 · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q99PF4
- Elsewhere: RCSB PDB 5TFL · PDBe 5TFL · UniProt Q99PF4
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