MolNFT v1 · #13468 · protein
SH3-SH2 domain fragment of human P56-lck tyrosine kinase complexed with the 10 residue synthetic phosphotyrosyl peptide tegqpyqpqpa
1LCK · P56==LCK== tyrosine kinase: “SH3-SH2 domain fragment of human P56-lck tyrosine kinase complexed with the 10 residue synthetic…”. X-ray diffraction. MolNFT v1 #13468 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1LCK
- Type
- protein
- Length
- 173 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- P56==LCK== tyrosine kinase; Tail phosphopeptide TEGQ(PHOSPHO)YQPQPA
- EC
- 2.7.1.112
- UniProt
- P06239
Structure
x-ray diffraction · 2 distinct chains · 12% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | P56==LCK== tyrosine kinase (EC 2.7.1.112) | protein | 164 | 12% helix, 33% strand | P06239 |
| B | Tail phosphopeptide TEGQ(PHOSPHO)YQPQPA | protein | 9 | 0% helix, 0% strand | P06239 |
Interfaces
1 interface between chains.
- A–B · 580 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 1 modified (phosphorylation).
Compared structures
- 1LCK · SH3-SH2 domain fragment of human P56-lck tyrosine kinase complexed with the 10 residue… · the same entry in another collection · chain A against A, TM-score 1.00
- P06239 · AlphaFold monomer V2.0 prediction for tyrosine-protein kinase lck (P06239) · a predicted model of the same protein · chain A against A, TM-score 0.63
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P06239
- Elsewhere: RCSB PDB 1LCK · PDBe 1LCK · UniProt P06239
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