MolNFT v1 · #134672 · protein
Human beta cardiac heavy meromyosin interacting-heads motif obtained by homology modeling (using swiss-model) of human sequence from aphonopelma homology model (pdb-3JBH), rigidly fitted to human beta- cardiac negatively stained thick filament 3D-reconstruction (emd- 2240)
5TBY · Myosin-7: “Human beta cardiac heavy meromyosin interacting-heads motif obtained by homology modeling (using swiss-model)…”. Electron microscopy, 20 pockets (best druggability 0.87). MolNFT v1 #134672 on GenesisL1: 3D structure…
- PDB
- 5TBY
- Type
- protein
- Length
- 2,528 residues
- Chains
- 6
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Myosin-7; Myosin light chain 3; Myosin regulatory light chain 2, VENTRICULAR/CARDIAC…
- UniProt
- P12883, P08590, P10916
- Pockets
- 20 · best druggability 0.87
Structure
electron microscopy · 4 distinct chains · 47% helix, 10% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Myosin-7 | protein | 954 | 46% helix, 10% strand | P12883 |
| B | Myosin-7 | protein | 950 | 47% helix, 11% strand | P12883 |
| C, D | Myosin light chain 3 | protein | 152 | 51% helix, 8% strand | P08590 |
| E, F | Myosin regulatory light chain 2, VENTRICULAR/CARDIAC muscle isoform | protein | 160 | 44% helix, 5% strand | P10916 |
Pockets
20 pockets found on a 1 Å grid, 20 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1055 | 0.87 | 0.87 | 117 | empty |
| 2 | 722 | 0.86 | 0.89 | 81 | empty |
| 3 | 576 | 0.83 | 0.89 | 74 | empty |
| 4 | 921 | 0.82 | 0.84 | 105 | empty |
| 5 | 169 | 0.81 | 0.95 | 38 | empty |
Interfaces
12 interfaces between chains.
- A–B · 5109 Ų buried · 64 hydrogen bonds · protein-protein
- B–D · 2706 Ų buried · 57 hydrogen bonds · protein-protein
- A–E · 2164 Ų buried · 34 hydrogen bonds · protein-protein
- B–F · 2024 Ų buried · 44 hydrogen bonds · protein-protein
- A–C · 1643 Ų buried · 42 hydrogen bonds · protein-protein
Compared structures
- 5TBY · Human beta cardiac heavy meromyosin interacting-heads motif obtained by homology modeling… · the same entry in another collection · chain F against F, TM-score 1.00
- P08590 · AlphaFold monomer V2.0 prediction for myosin light chain 3 (P08590) · a predicted model of the same protein · chain C against A, TM-score 0.88
- P12883 · AlphaFold monomer V2.0 prediction for myosin-7 (P12883) · a predicted model of the same protein · chain B against A, TM-score 0.81
- P10916 · AlphaFold monomer V2.0 prediction for myosin regulatory light chain 2… · a predicted model of the same protein · chain E against A, TM-score 0.62
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P12883
- Every structure of UniProt P08590
- Every structure of UniProt P10916
- Elsewhere: RCSB PDB 5TBY · PDBe 5TBY · UniProt P12883 · UniProt P08590 · UniProt P10916
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.