MolNFT v1 · #134658 · protein
Crystal structure of mouse CARM1 in complex with inhibitor LH1427
5TBI: “Crystal structure of mouse CARM1 in complex with inhibitor LH1427”. X-ray diffraction, 1 ligand (78V). MolNFT v1 #134658 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5TBI
- Type
- protein
- Length
- 1,372 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q9WVG6
- Ligands
- 78V
Structure
x-ray diffraction · 3 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | — | protein | 344 | — | Q9WVG6 |
| B | — | protein | 343 | — | Q9WVG6 |
| D | — | protein | 341 | — | Q9WVG6 |
Ligands and binding sites
- 78V · 4-[2-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methylamino]ethylamino]-1-(methoxymethyl)pyrimidin-2-one · ligand · 2 copies · chains B, D
- EDO · 1,2-ethanediol · additive · 17 copies · chains A, D, B, C
- PE8 · 3,6,9,12,15,18,21-heptaoxatricosane-1,23-diol · additive · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5TBI · Crystal structure of mouse CARM1 in complex with inhibitor LH1427 · the same entry in another collection · chain B against B, TM-score 1.00
- Q9WVG6 · AlphaFold monomer V2.0 prediction for histone-arginine methyltransferase CARM1 (Q9WVG6) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9WVG6
- Elsewhere: RCSB PDB 5TBI · PDBe 5TBI · UniProt Q9WVG6
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