Precatalytic ternary complex of human DNA polymerase beta in closed conformation with gapped DNA substrate incoming (-)ftc-tp and MN2+.

Structure

x-ray diffraction · 4 distinct chains.

Ligands and binding sites

• 1RY · [[(2R,5S)-5-(4-azanyl-5-fluoranyl-2-oxidanylidene-pyrimidin-1-yl)-1,3-oxathiolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate · ligand · chains A, P, T
• MN · Manganese (II) ion · metal · 6 copies · chains A, P
• NA · Sodium ion · metal · 4 copies · chains A, D, P
• ACT · Acetate ion · additive · 3 copies · chains A, T

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 5TB9 · Precatalytic ternary complex of Human DNA Polymerase Beta in closed conformation With… · the same entry in another collection · chain A against A, TM-score 1.00
• P06746 · AlphaFold monomer V2.0 prediction for DNA polymerase beta (P06746) · a predicted model of the same protein · chain A against A, TM-score 0.92

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P06746
• Elsewhere: RCSB PDB 5TB9 · PDBe 5TB9 · UniProt P06746