MolNFT v1 · #134559 · protein
A6-A11 trans-dicarba human insulin
5T7R · Insulin a chain: “A6-A11 trans-dicarba human insulin”. X-ray diffraction. MolNFT v1 #134559 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5T7R
- Type
- protein
- Length
- 100 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Insulin a chain; Insulin B chain
- UniProt
- P01308
Structure
x-ray diffraction · 2 distinct chains · 52% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | Insulin a chain | protein | 21 | 57% helix, 10% strand | P01308 |
| B, D | Insulin B chain | protein | 29 | 48% helix, 14% strand | P01308 |
Interfaces
5 interfaces between chains.
- C–D · 854 Ų buried · 8 hydrogen bonds · protein-protein
- A–B · 821 Ų buried · 15 hydrogen bonds · protein-protein
- B–D · 568 Ų buried · 8 hydrogen bonds · protein-protein
- B–C · 66 Ų buried · 1 hydrogen bond · protein-protein
- A–D · 50 Ų buried · 1 hydrogen bond · protein-protein
Modifications
Observed in the structure: 4 disulfide, 4 modified (disulfide, nonstandard).
Compared structures
- 5T7R · A6-A11 trans-dicarba human insulin · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01308
- Elsewhere: RCSB PDB 5T7R · PDBe 5T7R · UniProt P01308
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