MolNFT v1 · #13449 · protein
Crystal structure of a complex (P32 crystal form) of dual activity FBPASE/IMPASE (AF2372) from archaeoglobus fulgidus with 3 manganese ions, fructose-6-phosphate, and phosphate ion
1LBY · Fructose 1,6-BISPHOSPHATASE/INOSITOL monophosphatase: “Crystal structure of a complex (P32 crystal form) of dual activity FBPASE/IMPASE (AF2372) from archaeoglobus…”. X-ray diffraction, 3 ligands (F6P, MN, PO4), 6 pockets (best…
- PDB
- 1LBY
- Type
- protein
- Length
- 504 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Fructose 1,6-BISPHOSPHATASE/INOSITOL monophosphatase
- EC
- 3.1.3.11, 3.1.3.25
- UniProt
- O30298
- Ligands
- F6P, MN, PO4
- Pockets
- 6 · best druggability 0.70
Structure
x-ray diffraction · 1 distinct chain · 31% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Fructose 1,6-BISPHOSPHATASE/INOSITOL monophosphatase (EC 3.1.3.11, 3.1.3.25) | protein | 252 | 31% helix, 30% strand | O30298 |
Ligands and binding sites
- F6P · 6-O-phosphono-beta-D-fructofuranose · ligand · 2 copies · chains A, B
- MN · Manganese (II) ion · metal · 6 copies · chains A, B
- PO4 · Phosphate ion · ion · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 391 | 0.70 | 0.82 | 33 | F6P, PO4 |
| 2 | 396 | 0.69 | 0.81 | 34 | F6P, MN, PO4 |
| 3 | 142 | 0.40 | 0.74 | 34 | empty |
| 4 | 101 | 0.35 | 0.74 | 13 | empty |
| 5 | 57 | 0.32 | 0.77 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 1200 Ų buried · 13 hydrogen bonds · protein-protein
Compared structures
- 1LBY · Crystal Structure of a complex (P32 crystal form) of dual activity FBPase/IMPase (AF2372)… · the same entry in another collection · chain A against A, TM-score 1.00
- O30298 · AlphaFold monomer V2.0 prediction for fructose-1,6-BISPHOSPHATASE/INOSITOL-1-monophosphata… · a predicted model of the same protein · chain B against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O30298
- Elsewhere: RCSB PDB 1LBY · PDBe 1LBY · UniProt O30298
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.