MolNFT v1 · #134238 · protein

Atomic resolution structure of human dj-1, dtt bound

5SY6 · Protein deglycase dj-1: “Atomic resolution structure of human dj-1, dtt bound”. X-ray diffraction, 1 pocket (best druggability 0.37). MolNFT v1 #134238 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5SY6
Type: protein
Length: 187 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein deglycase dj-1
EC: 3.1.2.-, 3.5.1.-
UniProt: Q99497
Pockets: 1 · best druggability 0.37

Structure

x-ray diffraction · 1 distinct chain · 43% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein deglycase dj-1 (EC 3.1.2.-, 3.5.1.-)	protein	187	43% helix, 21% strand	Q99497

Ligands and binding sites

DTT · 2,3-dihydroxy-1,4-dithiobutane · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	52	0.37	0.80	13	empty

Compared structures

5SY6 · Atomic resolution structure of human DJ-1, DTT bound · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q99497
Elsewhere: RCSB PDB 5SY6 · PDBe 5SY6 · UniProt Q99497

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