MolNFT v1 · #134223 · protein
Structural basis for the interaction between itch prr and beta-pix
5SXP · Rho guanine nucleotide exchange factor 7: “Structural basis for the interaction between itch prr and beta-pix”. X-ray diffraction, 1 pocket (best druggability 0.33). MolNFT v1 #134223 on GenesisL1: 3D structure, binding sites and…
- PDB
- 5SXP
- Type
- protein
- Length
- 282 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Rho guanine nucleotide exchange factor 7; E3 ubiquitin-protein ligase itchy homolog
- EC
- 6.3.2.-
- UniProt
- Q14155, Q96J02
- Pockets
- 1 · best druggability 0.33
Structure
x-ray diffraction · 4 distinct chains · 4% helix, 37% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Rho guanine nucleotide exchange factor 7 | protein | 61 | 5% helix, 48% strand | Q14155 |
| C, D | Rho guanine nucleotide exchange factor 7 | protein | 60 | 5% helix, 50% strand | Q14155 |
| F | E3 ubiquitin-protein ligase itchy homolog (EC 6.3.2.-) | protein | 19 | 0% helix, 0% strand | Q96J02 |
| G | E3 ubiquitin-protein ligase itchy homolog (EC 6.3.2.-) | protein | 21 | 0% helix, 0% strand | Q96J02 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 85 | 0.33 | 0.74 | 23 | empty |
Interfaces
8 interfaces between chains.
- A–B · 906 Ų buried · 24 hydrogen bonds · protein-protein
- C–G · 687 Ų buried · 10 hydrogen bonds · protein-protein
- B–F · 648 Ų buried · 7 hydrogen bonds · protein-protein
- D–F · 411 Ų buried · 7 hydrogen bonds · protein-protein
- A–G · 402 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- Q14155 · AlphaFold monomer V2.0 prediction for rho guanine nucleotide exchange factor 7 (Q14155) · a predicted model of the same protein · chain A against A, TM-score 0.93
- Q96J02 · AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase itchy homolog (Q96J02) · a predicted model of the same protein · chain F against A, TM-score 0.25
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14155
- Every structure of UniProt Q96J02
- Elsewhere: RCSB PDB 5SXP · PDBe 5SXP · UniProt Q14155 · UniProt Q96J02
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.