UniProt Q96J02
E3 ubiquitin-protein ligase Itchy homolog (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (UniProt Q96J02), EC 6.3.2.-: 23 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 1 pocket. Binding sites, druggability and experiment against prediction…
- UniProt
- Q96J02
- Protein
- E3 ubiquitin-protein ligase Itchy homolog
- EC
- 6.3.2.-
- Experimental structures
- 23
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 1 · 0 records with a druggable one
Structures
24 records of Q96J02 in the MolNFT archive: 23 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2DMV | Solution structure of the second ww domain of Itchy homolog E3 ubiquitin protein ligase (Itch) | solution nmr | A | — | — |
| 2DMV | Solution structure of the second ww domain of itchy homolog E3 ubiquitin protein ligase (itch) | solution nmr | A | — | — |
| 2KYK | The sandwich region between two LMP2A PY motif regulates the interaction between AIP4WW2domain and… | solution nmr | A | — | — |
| 2KYK | The sandwich region between two LMP2A py motif regulates the interaction between AIP4WW2DOMAIN and… | solution nmr | A | — | — |
| 2NQ3 | Crystal structure of the C2 Domain of Human Itchy Homolog E3 Ubiquitin Protein Ligase | x-ray diffraction | A | — | — |
| 2NQ3 | Crystal structure of the C2 domain of human itchy homolog E3 ubiquitin protein ligase | x-ray diffraction | A | — | — |
| 2P4R | Structural basis for a novel interaction between AIP4 and beta-PIX | x-ray diffraction | T | — | — |
| 2P4R | Structural basis for a novel interaction between AIP4 and beta-pix | x-ray diffraction | T | — | — |
| 2YSF | Solution structure of the fourth WW domain from the human E3 ubiquitin-protein ligase Itchy… | solution nmr | A | — | — |
| 2YSF | Solution structure of the fourth ww domain from the human E3 ubiquitin-protein ligase itchy… | solution nmr | A | — | — |
| 3TUG | Crystal structure of the HECT domain of ITCH E3 ubiquitin ligase | x-ray diffraction | A | — | — |
| 3TUG | Crystal structure of the hect domain of itch E3 ubiquitin ligase | x-ray diffraction | A | — | — |
| 4ROF | Crystal Structure of WW3 domain of ITCH in complex with TXNIP peptide | x-ray diffraction | A, B | — | — |
| 4ROF | Crystal structure of WW3 domain of itch in complex with txnip peptide | x-ray diffraction | A, B | — | — |
| 5C7M | Crystal structure of E3 ligase itch with a ub variant | x-ray diffraction | A | — | — |
| 5C7M | Crystal structure of E3 ligase itch with a ub variant | x-ray diffraction | A | — | — |
| 5CQ2 | Crystal Structure of tandem WW domains of ITCH in complex with TXNIP peptide | x-ray diffraction | A | UNX | — |
| 5CQ2 | Crystal structure of tandem ww domains of itch in complex with txnip peptide | x-ray diffraction | A | — | — |
| 5DWS | Crystal Structure of ITCH WW3 domain in complex with TXNIP peptide | x-ray diffraction | A, C, E, G | UNX | 1 (best 0.32) |
| 5DWS | Crystal structure of itch WW3 domain in complex with txnip peptide | x-ray diffraction | A, C, E, G | — | — |
| 5DZD | Crystal Structure of WW4 domain of ITCH in complex with TXNIP peptide | x-ray diffraction | A, B | UNX | — |
| 5DZD | Crystal structure of WW4 domain of itch in complex with txnip peptide | x-ray diffraction | A, B | — | — |
| 5SXP | Structural basis for the interaction between itch prr and beta-pix | x-ray diffraction | F, G | — | — |
| Q96J02 | AlphaFold monomer V2.0 prediction for E3 ubiquitin-protein ligase itchy homolog (Q96J02) | predicted | A | — | — |
Ligands
- UNX · Unknown atom or ion · in 3 records
Experiment against prediction
- 2NQ3 chain A against the predicted model Q96J02: TM-score 0.99, RMSD 0.47 Å
- 2NQ3 chain A against the predicted model Q96J02: TM-score 0.99, RMSD 0.47 Å
- 5C7M chain A against the predicted model Q96J02: TM-score 0.96, RMSD 1.53 Å
- 5C7M chain A against the predicted model Q96J02: TM-score 0.96, RMSD 1.53 Å
- 3TUG chain A against the predicted model Q96J02: TM-score 0.96, RMSD 1.48 Å
- 3TUG chain A against the predicted model Q96J02: TM-score 0.96, RMSD 1.48 Å
- 5DZD chain A against the predicted model Q96J02: TM-score 0.95, RMSD 0.43 Å
- 5DZD chain A against the predicted model Q96J02: TM-score 0.95, RMSD 0.43 Å
- 5DZD chain B against the predicted model Q96J02: TM-score 0.94, RMSD 0.47 Å
- 5DZD chain B against the predicted model Q96J02: TM-score 0.94, RMSD 0.47 Å
Elsewhere
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