MolNFT v1 · #134146 · protein
MORC3 cw domain in complex with unmodified histone H3
5SVI · Morc family cw-type zinc finger protein 3: “MORC3 cw domain in complex with unmodified histone H3”. X-ray diffraction, 1 ligand (ZN), 1 pocket (best druggability 0.42). MolNFT v1 #134146 on GenesisL1: 3D structure, binding sites and…
- PDB
- 5SVI
- Type
- protein
- Length
- 115 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Morc family cw-type zinc finger protein 3; Ala-arg-thr-lys-gln-thr-ala-arg
- UniProt
- Q14149
- Ligands
- ZN
- Pockets
- 1 · best druggability 0.42
Structure
x-ray diffraction · 3 distinct chains · 11% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Morc family cw-type zinc finger protein 3 | protein | 46 | 13% helix, 20% strand | Q14149 |
| B | Morc family cw-type zinc finger protein 3 | protein | 53 | 11% helix, 17% strand | Q14149 |
| C, D | Ala-arg-thr-lys-gln-thr-ala-arg | protein | 8 | 0% helix, 50% strand | — |
Ligands and binding sites
- ZN · Zinc ion · metal · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 136 | 0.42 | 0.75 | 21 | empty |
Interfaces
6 interfaces between chains.
- B–D · 638 Ų buried · 18 hydrogen bonds · protein-protein
- A–C · 580 Ų buried · 20 hydrogen bonds · protein-protein
- A–B · 185 Ų buried · 2 hydrogen bonds · protein-protein
- C–D · 181 Ų buried · 2 hydrogen bonds · protein-protein
- A–D · 153 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 5SVI · MORC3 CW domain in complex with unmodified histone H3 · the same entry in another collection · chain A against A, TM-score 1.00
- Q14149 · AlphaFold monomer V2.0 prediction for morc family cw-type zinc finger protein 3 (Q14149) · a predicted model of the same protein · chain A against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q14149
- Elsewhere: RCSB PDB 5SVI · PDBe 5SVI · UniProt Q14149
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