MolNFT v1 · #13343 · protein
Crystal structure of the endothelial protein C receptor and bound phospholipid molecule
1L8J: “Crystal structure of the endothelial protein C receptor and bound phospholipid molecule”. X-ray diffraction, 3 ligands (PTY, NAG, NDG), 1 pocket (best druggability 0.82). MolNFT v1 #13343 on GenesisL1: 3D structure, binding sites…
- PDB
- 1L8J
- Type
- protein
- Length
- 170 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Endothelial protein C receptor
- UniProt
- Q9UNN8
- Ligands
- PTY, NAG, NDG
- Pockets
- 1 · best druggability 0.82
Structure
x-ray diffraction · 1 distinct chain · 37% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Endothelial protein C receptor | protein | 170 | 37% helix, 39% strand | Q9UNN8 |
Ligands and binding sites
- PTY · Phosphatidylethanolamine · ligand · chains A
- NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose · sugar · 5 copies · chains A
- NDG · 2-acetamido-2-deoxy-alpha-D-glucopyranose · sugar
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 589 | 0.82 | 0.87 | 61 | PTY |
Modifications
Observed in the structure: 3 glycan, 1 disulfide (N-glycosylation, disulfide).
Compared structures
- 1L8J · Crystal Structure of the Endothelial Protein C Receptor and Bound Phospholipid Molecule · the same entry in another collection · chain A against A, TM-score 1.00
- Q9UNN8 · AlphaFold monomer V2.0 prediction for endothelial protein C receptor (Q9UNN8) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9UNN8
- Elsewhere: RCSB PDB 1L8J · PDBe 1L8J · UniProt Q9UNN8
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