UniProt Q9UNN8
Endothelial protein C receptor (Q9UNN8)
Endothelial protein C receptor (UniProt Q9UNN8): 21 experimental structures and 1 predicted model on GenesisL1, 7 ligands bound, 21 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q9UNN8
- Protein
- Endothelial protein C receptor
- Experimental structures
- 21
- Predicted models
- 1
- Ligands
- 7
- Pockets
- 21 · 6 records with a druggable one
Structures
22 records of Q9UNN8 in the MolNFT archive: 21 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1L8J | Crystal Structure of the Endothelial Protein C Receptor and Bound Phospholipid Molecule | x-ray diffraction | A | — | — |
| 1L8J | Crystal structure of the endothelial protein C receptor and bound phospholipid molecule | x-ray diffraction | A | — | — |
| 1LQV | Crystal structure of the Endothelial protein C receptor with phospholipid in the groove in complex… | x-ray diffraction | A, B | — | — |
| 1LQV | Crystal structure of the endothelial protein C receptor with phospholipid in the groove in complex… | x-ray diffraction | A, B | — | — |
| 3JTC | Importance of Mg2+ in the Ca2+-Dependent Folding of the gamma-Carboxyglutamic Acid Domains of… | x-ray diffraction | A, B | — | — |
| 3JTC | Importance of MG2+ in the CA2+-dependent folding of the gamma- carboxyglutamic acid domains of… | x-ray diffraction | A, B | — | — |
| 4V3D | The CIDRa domain from HB3var03 PfEMP1 bound to endothelial protein C receptor | x-ray diffraction | B, D | — | — |
| 4V3D | The cidra domain from HB3VAR03 PFEMP1 bound to endothelial protein C receptor | x-ray diffraction | B, D | — | — |
| 4V3E | The CIDRa domain from IT4var07 PfEMP1 bound to endothelial protein C receptor | x-ray diffraction | B | — | — |
| 4V3E | The cidra domain from IT4VAR07 PFEMP1 bound to endothelial protein C receptor | x-ray diffraction | B | — | — |
| 6SNY | Synthetic mimic of an EPCR-binding PfEMP1 bound to EPCR | x-ray diffraction | B, C | NAG, PTY | 6 (best 0.82) |
| 6SNY | Synthetic mimic of an epcr-binding PFEMP1 bound to epcr | x-ray diffraction | B, C | NAG, PTY | — |
| 7OKS | X-ray structure of soluble EPCR in P212121 space group | x-ray diffraction | A, B, C, D | NAG, FUC, MAN, PTY | 8 (best 0.83) |
| 7OKS | X-ray structure of soluble epcr in P212121 space group | x-ray diffraction | A, B, C, D | NAG, FUC, MAN, PTY | — |
| 7OKT | X-ray structure of soluble EPCR in C2221 space group | x-ray diffraction | A, B | NAG, FUC, PTY | 3 (best 0.86) |
| 7OKT | X-ray structure of soluble epcr in C2221 space group | x-ray diffraction | A, B | NAG, FUC, PTY | — |
| 7OKU | X-ray structure of soluble EPCR in P3121 space group | x-ray diffraction | A | NAG, PTY | 1 (best 0.80) |
| 7OKU | X-ray structure of soluble epcr in P3121 space group | x-ray diffraction | A | NAG, PTY | — |
| 7OKV | Crystal structure of soluble epcr after exposure to the nonionic surfactant polysorbate 20 | x-ray diffraction | A | NAG, R16, D10 | — |
| 7Q5D | Structure of EPCR in a non-canonical conformation | x-ray diffraction | A | NAG, CYS, PTY | 1 (best 0.81) |
| 8C44 | HB3VAR03 apo headstructure (PfEMP1 A) complexed with EPCR | electron microscopy | C | PTY, NAG | 2 (best 0.82) |
| Q9UNN8 | AlphaFold monomer V2.0 prediction for endothelial protein C receptor (Q9UNN8) | predicted | A | — | — |
Ligands
Experiment against prediction
- 1LQV chain A against the predicted model Q9UNN8: TM-score 1.00, RMSD 0.36 Å
- 1LQV chain A against the predicted model Q9UNN8: TM-score 1.00, RMSD 0.36 Å
- 3JTC chain A against the predicted model Q9UNN8: TM-score 1.00, RMSD 0.36 Å
- 3JTC chain A against the predicted model Q9UNN8: TM-score 1.00, RMSD 0.36 Å
- 4V3D chain D against the predicted model Q9UNN8: TM-score 1.00, RMSD 0.34 Å
- 4V3D chain D against the predicted model Q9UNN8: TM-score 1.00, RMSD 0.34 Å
- 4V3D chain B against the predicted model Q9UNN8: TM-score 0.99, RMSD 0.36 Å
- 4V3D chain B against the predicted model Q9UNN8: TM-score 0.99, RMSD 0.36 Å
- 7OKS chain B against the predicted model Q9UNN8: TM-score 0.99, RMSD 0.37 Å
- 7OKS chain B against the predicted model Q9UNN8: TM-score 0.99, RMSD 0.37 Å
Elsewhere
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