MolNFT v1 · #13340 · protein
Crystal structure of PTP1B complexed with 7-(1,1-dioxo-1H- BENZO[D]ISOTHIAZOL-3-yloxymethyl)-2-(oxalyl-amino)-4,7- dihydro-5H-THIENO[2,3-C]PYRAN-3-carboxylic acid
1L8G · Protein-tyrosine phosphatase, non-receptor type 1: “Crystal structure of PTP1B complexed with 7-(1,1-dioxo-1H…”. X-ray diffraction, 1 ligand (DBD). MolNFT v1 #13340 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1L8G
- Type
- protein
- Length
- 297 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein-tyrosine phosphatase, non-receptor type 1
- EC
- 3.1.3.48
- UniProt
- P18031
- Ligands
- DBD
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 21% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein-tyrosine phosphatase, non-receptor type 1 (EC 3.1.3.48) | protein | 297 | 38% helix, 21% strand | P18031 |
Ligands and binding sites
- DBD · 7-(1,1-dioxo-1H-benzo[d]isothiazol-3-yloxymethyl)-2-(oxalyl-amino)-4,7-dihydro-5H-thieno[2,3-c]pyran-3-carboxylic acid · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 1L8G · Crystal structure of PTP1B complexed with 7-(1,1-Dioxo-1H-benzo[d]isothiazol-3-yloxymethyl… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P18031
- Elsewhere: RCSB PDB 1L8G · PDBe 1L8G · UniProt P18031
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