MolNFT v1 · #13260 · protein
The 2.0-ångström resolution crystal structure of a survival protein E (sure) homolog from pyrobaculum aerophilum
1L5X: “The 2.0-ångström resolution crystal structure of a survival protein E (sure) homolog from pyrobaculum…”. X-ray diffraction, 2 pockets (best druggability 0.71). MolNFT v1 #13260 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 1L5X
- Type
- protein
- Length
- 554 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Survival protein E
- UniProt
- Q8ZU79
- Pockets
- 2 · best druggability 0.71
Structure
x-ray diffraction · 2 distinct chains · 33% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Survival protein E | protein | 276 | 34% helix, 24% strand | Q8ZU79 |
| B | Survival protein E | protein | 278 | 32% helix, 24% strand | Q8ZU79 |
Ligands and binding sites
- GOL · Glycerol · additive · 7 copies · chains A, B
- ACY · Acetic acid · additive · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 638 | 0.71 | 0.79 | 77 | GOL, ACY |
| 2 | 82 | 0.35 | 0.75 | 25 | empty |
Interfaces
1 interface between chains.
- A–B · 3011 Ų buried · 35 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 12 modified (engineered).
Compared structures
- 1L5X · The 2.0-Angstrom resolution crystal structure of a survival protein E (SurE) homolog from… · the same entry in another collection · chain A against A, TM-score 1.00
- Q8ZU79 · AlphaFold monomer V2.0 prediction for 5'-nucleotidase SURE1 (Q8ZU79) · a predicted model of the same protein · chain A against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8ZU79
- Elsewhere: RCSB PDB 1L5X · PDBe 1L5X · UniProt Q8ZU79
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