MolNFT v1 · #13244 · protein
Femo-cofactor deficient nitrogenase mofe protein
1L5H · Nitrogenase molybdenum-iron protein alpha chain: “Femo-cofactor deficient nitrogenase mofe protein”. X-ray diffraction, 2 ligands (CLF, CA), 9 pockets (best druggability 0.80). MolNFT v1 #13244 on GenesisL1: 3D structure, binding…
- PDB
- 1L5H
- Type
- protein
- Length
- 927 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nitrogenase molybdenum-iron protein alpha chain; Nitrogenase molybdenum-iron protein beta…
- EC
- 1.18.6.1
- UniProt
- P07328, P07329
- Ligands
- CLF, CA
- Pockets
- 9 · best druggability 0.80
Structure
x-ray diffraction · 2 distinct chains · 48% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Nitrogenase molybdenum-iron protein alpha chain (EC 1.18.6.1) | protein | 405 | 45% helix, 13% strand | P07328 |
| B | Nitrogenase molybdenum-iron protein beta chain (EC 1.18.6.1) | protein | 522 | 51% helix, 10% strand | P07329 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
9 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 959 | 0.80 | 0.82 | 87 | empty |
| 2 | 76 | 0.75 | 0.99 | 30 | empty |
| 3 | 67 | 0.74 | 0.98 | 21 | CLF |
| 4 | 63 | 0.56 | 0.89 | 26 | empty |
| 5 | 105 | 0.50 | 0.81 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 4246 Ų buried · 50 hydrogen bonds · protein-protein
Compared structures
- 1L5H · FeMo-cofactor Deficient Nitrogenase MoFe Protein · the same entry in another collection · chain A against A, TM-score 1.00
- P07329 · AlphaFold monomer V2.0 prediction for nitrogenase molybdenum-iron protein beta chain… · a predicted model of the same protein · chain B against A, TM-score 1.00
- P07328 · AlphaFold monomer V2.0 prediction for nitrogenase molybdenum-iron protein alpha chain… · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P07328
- Every structure of UniProt P07329
- Elsewhere: RCSB PDB 1L5H · PDBe 1L5H · UniProt P07328 · UniProt P07329
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