MolNFT v1 · #132275 · protein
Pandda analysis group deposition -- crystal structure of human brachyury G177D variant in complex with Z48847594
5QS9 · T-box transcription factor T: “Pandda analysis group deposition -- crystal structure of human brachyury G177D variant in complex with…”. X-ray diffraction, 1 ligand (O0J), 1 pocket (best druggability 0.44). MolNFT v1 #132275 on…
- PDB
- 5QS9
- Type
- protein
- Length
- 171 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- T-box transcription factor T
- UniProt
- O15178
- Ligands
- O0J
- Pockets
- 1 · best druggability 0.44
Structure
x-ray diffraction · 1 distinct chain · 17% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | T-box transcription factor T | protein | 171 | 17% helix, 39% strand | O15178 |
Ligands and binding sites
- O0J · N-[4-(2-amino-1,3-thiazol-4-yl)phenyl]acetamide · ligand · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 73 | 0.44 | 0.81 | 24 | empty |
Compared structures
- 5QS9 · PanDDA analysis group deposition -- Crystal Structure of human Brachyury G177D variant in… · the same entry in another collection · chain A against A, TM-score 1.00
- O15178 · AlphaFold monomer V2.0 prediction for T-box transcription factor T (O15178) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O15178
- Elsewhere: RCSB PDB 5QS9 · PDBe 5QS9 · UniProt O15178
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