MolNFT v1 · #132202 · protein
Pandda analysis group deposition -- crystal structure of T. cruzi fpps in complex with FMOOA000563A
5QQ8 · Farnesyl diphosphate synthase: “Pandda analysis group deposition -- crystal structure of T. cruzi fpps in complex with FMOOA000563A”. X-ray diffraction, 3 ligands (LXS, ZN, SO4), 2 pockets (best druggability 0.79). MolNFT v1 #132202…
- PDB
- 5QQ8
- Type
- protein
- Length
- 360 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Farnesyl diphosphate synthase
- UniProt
- Q8WS26
- Ligands
- LXS, ZN, SO4
- Pockets
- 2 · best druggability 0.79
Structure
x-ray diffraction · 1 distinct chain · 74% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Farnesyl diphosphate synthase | protein | 360 | 74% helix, 2% strand | Q8WS26 |
Ligands and binding sites
- LXS · 3-ethyl-1-[(1~{R},8~{S},9~{S},10~{S})-10-oxidanyl-11-oxatricyclo[6.2.1.0^{2,7}]undeca-2(7),3,5-trien-9-yl]imidazolidine-2,4-dione · ligand · chains A
- ZN · Zinc ion · metal · 2 copies · chains A
- SO4 · Sulfate ion · ion · 2 copies · chains A
- ACT · Acetate ion · additive · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 669 | 0.79 | 0.83 | 57 | SO4, ZN |
| 2 | 55 | 0.57 | 0.90 | 15 | empty |
Compared structures
- 5QQ8 · PanDDA analysis group deposition -- Crystal Structure of T. cruzi FPPS in complex with… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8WS26
- Elsewhere: RCSB PDB 5QQ8 · PDBe 5QQ8 · UniProt Q8WS26
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.