MolNFT v1 · #132175 · protein

Pandda analysis group deposition -- crystal structure of T. cruzi fpps in complex with FMOPL000315A

5QPH · Farnesyl diphosphate synthase: “Pandda analysis group deposition -- crystal structure of T. cruzi fpps in complex with FMOPL000315A”. X-ray diffraction, 3 ligands (LUS, ZN, SO4), 3 pockets (best druggability 0.78). MolNFT v1 #132175…

PDB: 5QPH
Type: protein
Length: 360 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Farnesyl diphosphate synthase
UniProt: Q8WS26
Ligands: LUS, ZN, SO4
Pockets: 3 · best druggability 0.78

Structure

x-ray diffraction · 1 distinct chain · 74% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Farnesyl diphosphate synthase	protein	360	74% helix, 1% strand	Q8WS26

Ligands and binding sites

LUS · 4-(4-ethylcyclohexyl)morpholine · ligand · chains A
ZN · Zinc ion · metal · 2 copies · chains A
SO4 · Sulfate ion · ion · 2 copies · chains A
ACT · Acetate ion · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	683	0.78	0.83	57	SO4, ZN, LUS
2	53	0.55	0.90	15	empty
3	53	0.33	0.77	12	empty

Compared structures

5QPH · PanDDA analysis group deposition -- Crystal Structure of T. cruzi FPPS in complex with… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8WS26
Elsewhere: RCSB PDB 5QPH · PDBe 5QPH · UniProt Q8WS26

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