MolNFT v1 · #13104 · protein + RNA
Structure of the lict bacterial antiterminator protein in complex with its RNA target
1L1C · Lict mRNA antiterminator hairpin: “Structure of the lict bacterial antiterminator protein in complex with its RNA target”. Solution nmr, 2 pockets (best druggability 0.32). MolNFT v1 #13104 on GenesisL1: 3D structure, binding sites…
- PDB
- 1L1C
- Type
- protein + RNA
- Length
- 139 residues
- Chains
- 3
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Lict mRNA antiterminator hairpin; Transcription antiterminator lict
- UniProt
- P39805
- Pockets
- 2 · best druggability 0.32
Structure
solution nmr · 2 distinct chains · 5% helix, 40% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| C | Lict mRNA antiterminator hairpin | rna | 29 | — | — |
| A, B | Transcription antiterminator lict | protein | 55 | 5% helix, 40% strand | P39805 |
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 67 | 0.32 | 0.75 | 15 | empty |
| 2 | 62 | 0.32 | 0.75 | 15 | empty |
Interfaces
3 interfaces between chains.
- A–B · 765 Ų buried · 15 hydrogen bonds · protein-protein
- C–B · 615 Ų buried · 19 hydrogen bonds · protein-nucleic
- C–A · 606 Ų buried · 19 hydrogen bonds · protein-nucleic
Compared structures
- 1L1C · Structure of the LicT Bacterial Antiterminator Protein in Complex with its RNA Target · the same entry in another collection · chain C against C, TM-score 1.00
- P39805 · AlphaFold monomer V2.0 prediction for transcription antiterminator lict (P39805) · a predicted model of the same protein · chain A against A, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P39805
- Elsewhere: RCSB PDB 1L1C · PDBe 1L1C · UniProt P39805
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