MolNFT v1 · #1310 · protein
Immune versus natural selection: antibody aldolases with the rates of natural enzymes
1AXT · Immunoglobulin IGG2A: “Immune versus natural selection: antibody aldolases with the rates of natural enzymes”. X-ray diffraction, 6 pockets (best druggability 0.69). MolNFT v1 #1310 on GenesisL1: 3D structure, binding sites and…
- PDB
- 1AXT
- Type
- protein
- Length
- 434 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Immunoglobulin IGG2A
- UniProt
- P01865
- Pockets
- 6 · best druggability 0.69
Structure
x-ray diffraction · 2 distinct chains · 6% helix, 54% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | Immunoglobulin IGG2A | protein | 216 | 6% helix, 53% strand | — |
| H | Immunoglobulin IGG2A | protein | 218 | 7% helix, 55% strand | P01865 |
Pockets
6 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 185 | 0.69 | 0.87 | 29 | empty |
| 2 | 514 | 0.61 | 0.75 | 75 | empty |
| 3 | 88 | 0.37 | 0.76 | 19 | empty |
| 4 | 91 | 0.32 | 0.73 | 16 | empty |
| 5 | 70 | 0.31 | 0.74 | 17 | empty |
Interfaces
1 interface between chains.
- L–H · 1743 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 1AXT · Immune versus natural selection: antibody aldolases with the rates of natural enzymes · the same entry in another collection · chain L against L, TM-score 1.00
- P01865 · AlphaFold monomer V2.0 prediction for ig gamma-2A chain C region, membrane-bound form… · a predicted model of the same protein · chain H against A, TM-score 0.50
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01865
- Elsewhere: RCSB PDB 1AXT · PDBe 1AXT · UniProt P01865
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