MolNFT v1 · #130496 · protein
X-ray analyses of aspartic proteases. II. three-dimensional structure of the hexagonal crystal form of porcine pepsin at 2.3 ångströms resolution
5PEP: “X-ray analyses of aspartic proteases. II. three-dimensional structure of the hexagonal crystal form of…”. X-ray diffraction, 2 pockets (best druggability 0.63). MolNFT v1 #130496 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 5PEP
- Type
- protein
- Length
- 326 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Pepsin
- EC
- 3.4.23.1
- UniProt
- P00791
- Pockets
- 2 · best druggability 0.63
Structure
x-ray diffraction · 1 distinct chain · 13% helix, 45% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Pepsin (EC 3.4.23.1) | protein | 326 | 13% helix, 45% strand | P00791 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 315 | 0.63 | 0.79 | 39 | empty |
| 2 | 54 | 0.28 | 0.75 | 16 | empty |
Modifications
Observed in the structure: 3 disulfide (disulfide).
Compared structures
- 5PEP · X-ray analyses of aspartic proteases. II. three-dimensional structure of the hexagonal… · the same entry in another collection · chain A against A, TM-score 1.00
- P00791 · AlphaFold monomer V2.0 prediction for pepsin a (P00791) · a predicted model of the same protein · chain A against A, TM-score 0.96
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00791
- Elsewhere: RCSB PDB 5PEP · PDBe 5PEP · UniProt P00791
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