MolNFT v1 · #12990 · protein

Cyclin H, a positive regulatory subunit of cdk activating kinase

1KXU: “Cyclin H, a positive regulatory subunit of cdk activating kinase”. X-ray diffraction, 5 pockets (best druggability 0.60). MolNFT v1 #12990 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1KXU
Type: protein
Length: 276 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Cyclin H
UniProt: P51946
Pockets: 5 · best druggability 0.60

Structure

x-ray diffraction · 1 distinct chain · 65% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Cyclin H	protein	276	65% helix, 0% strand	P51946

Pockets

5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	198	0.60	0.82	29	empty
2	99	0.40	0.77	18	empty
3	98	0.40	0.77	16	empty
4	50	0.28	0.75	11	empty
5	61	0.28	0.73	15	empty

Compared structures

1KXU · Cyclin H, a positive regulatory subunit of cdk activating kinase · the same entry in another collection · chain A against A, TM-score 1.00
P51946 · AlphaFold monomer V2.0 prediction for cyclin-H (P51946) · a predicted model of the same protein · chain A against A, TM-score 0.95

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P51946
Elsewhere: RCSB PDB 1KXU · PDBe 1KXU · UniProt P51946

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.