MolNFT v1 · #129807 · protein
RAS guanine nucleotide exchange factor SOS1 (rem-CDC25) in complex with small molecule inhibitor compound 21
5OVH: “RAS guanine nucleotide exchange factor SOS1 (rem-CDC25) in complex with small molecule inhibitor compound 21”. X-ray diffraction, 1 ligand (AWW). MolNFT v1 #129807 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 5OVH
- Type
- protein
- Length
- 455 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- UniProt
- Q07889
- Ligands
- AWW
Structure
x-ray diffraction · 1 distinct chain.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 455 | — | Q07889 |
Ligands and binding sites
- AWW · [2-[5-[(1~{R})-1-[(6,7-dimethoxy-2-methyl-5,8-dihydroquinazolin-4-yl)amino]ethyl]thiophen-2-yl]phenyl]methanol · ligand · chains A
- EDO · 1,2-ethanediol · additive · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5OVH · Ras guanine nucleotide exchange factor SOS1 (Rem-cdc25) in complex with small molecule… · the same entry in another collection · chain A against A, TM-score 1.00
- Q07889 · AlphaFold monomer V2.0 prediction for son of sevenless homolog 1 (Q07889) · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q07889
- Elsewhere: RCSB PDB 5OVH · PDBe 5OVH · UniProt Q07889
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